Characterization of the Mel1c melatoninergic receptor in platypus (Ornithorhynchus anatinus).
Melatonin is a neurohormone produced in both animals and plants.It binds at least three G-protein-coupled receptors: MT1 and MT2, and Mel1cGPR.Mammalian GPR50 evolved from the reptilian/avian Mel1c and lost its capacity to bind melatonin in all the therian mammal species that have been tested.In order to determine if binding is lost in the oldest s